There is a strong negative correlation between prostate cancer and circumcision rate across 181 countries (P<0.0001). Adding to the large protective effect of circumcision seen in small studies over the past six decades, a recent large study in Seattle has shown a smaller protective effect. If verified by other large studies elsewhere, the finding would add to the wide array of benefits conferred by this safe, simple procedure that is best performed in infancy.

Researchers at the Fred Hutchison Cancer Research Center in Seattle, WA, USA have reported recently that circumcision reduces the risk of aggressive prostate cancer by 18% and less aggressive prostate cancer by 12%, but only for circumcision prior to sexual debut.