Wazua
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HIV Cure now in sight
Rank: Elder Joined: 2/8/2013 Posts: 4,068 Location: At Large.
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Metaur wrote:Oh damn, I remember how nervous I was when I was needed to make those analysis for HIV. You can only imagine, thanks to the God all fine. But in the same time I am happy for people who maybe will have better lifes cause of that. It's serious issue of our generation. I am also worried that big pharma companies may be "worried" as well, about their ... money;) Am really worried about this Egrish.........the message might get lost. Love is beautiful and so are those who share it.With Love, Marriage is an amazing event in ones life time, the foundation of joy, happiness and success.
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Rank: Member Joined: 12/2/2006 Posts: 658
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I am losted already the communicacion
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Rank: Veteran Joined: 10/11/2009 Posts: 1,223
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murchr wrote:BGL Posted : Friday, December 27, 2013 wrote:Rankaz13 wrote:JkMwatha wrote:BGL wrote:........
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Question 1 is well answered so i will not repeat and will go to question 2 thanks @Rankaz13
It is [NOT] true that a patient with undetectable viral load cannot transmit infection but [IT IS VERY RARE]. At this point let me say that most of the replication is occurring in the LYMPHOID tissues while we are only sampling the blood tissue. However, you all know it depends on the route of transmission.
There are also some people whom HIV infection with some viruses (CCR5 tropic) is impossible. For instance 1-2% of Caucasians with delta32 CCR5 do not express a functional CCR5 and cannot be infected by CCR5 tropic viruses. In African populations (some in EA) we have delta24 CCR5 and the last time i did a flow cytometry experiment to assess expression it behaved the same way but this genotype but it is not well studied. There are also HLA variants that confer protection especially in discordant couples.
Good info BGL but boss,... come srow, come srow.... This is my question/scenerio (not their real names)Otieno hooks up with Nduku. Otieno suggests that they both go for a HIV tests. Nduku agrees, but has a hidden secret. She is positive but and has been on treatment for some time and viral load/count is undetectable. So she expects to show up as negative.... Even if they decided to go for repeat tests after six months, the results for Nduku will be the same as long as she remains on treatment. Is this a likely possibility? I think not. As long as the virus is there, even though the levels be low, the body will always mount an immune response to it i.e antibodies. And since the tests we routinely use are antibody-based, there you are. What say you @BGL?  I agree with you @Rankaz Infact even if functional cure occurs [IF WE WILL ever ACHIEVE THAT] you still have remnants of memory B cells which you can detect by Elisa. Where did these docs go to? NYTimes Article wrote:He had Hodgkin’s lymphoma and received a bone-marrow transplant from a donor with the CCR5 mutation in May 2016. He, too, received immunosuppressive drugs, but the treatment was much less intense, in line with current standards for transplant patients.
He quit taking anti-H.I.V. drugs in September 2017, making him the first patient since Mr. Brown known to remain virus-free for more than a year after stopping.
Although the London patient was not as ill as Mr. Brown had been after the transplant, the procedure worked about as well: The transplant destroyed the cancer without harmful side effects. The transplanted immune cells, now resistant to H.I.V., seem to have fully replaced his vulnerable cells.
Most people with the H.I.V.-resistant mutation, called delta 32, are of Northern European descent. IciStem maintains a database of about 22,000 such donors.
So far, its scientists are tracking 38 H.I.V.-infected people who have received bone-marrow transplants, including six from donors without the mutation.
Even if a person harbors only a small number of X4 viruses, they may multiply in the absence of competition from their viral cousins. There is at least one reported case of an individual who got a transplant from a delta 32 donor but later rebounded with the X4 virus. (As a precaution against X4, Mr. Brown is taking a daily pill to prevent H.I.V. infection.)
Heck! @BGL are you Dr. Gupta? Of course i am not Gupta i remain BGL. I am still working on a functional cure for HIV. However i am worried by the reduced PEPFAR funding by the Trump administration. If Kenya Government does not fill up the gaps we will roll back all the gains made. Tuko pamoja History will not remember you for your IQ. It will remember you for what you did. “Genius is 1 percent inspiration, 99 percent perspiration.” Thomas Edison
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Rank: Elder Joined: 2/26/2012 Posts: 15,980
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BGL wrote:murchr wrote:BGL Posted : Friday, December 27, 2013 wrote:Rankaz13 wrote:JkMwatha wrote:BGL wrote:........
.....
Question 1 is well answered so i will not repeat and will go to question 2 thanks @Rankaz13
It is [NOT] true that a patient with undetectable viral load cannot transmit infection but [IT IS VERY RARE]. At this point let me say that most of the replication is occurring in the LYMPHOID tissues while we are only sampling the blood tissue. However, you all know it depends on the route of transmission.
There are also some people whom HIV infection with some viruses (CCR5 tropic) is impossible. For instance 1-2% of Caucasians with delta32 CCR5 do not express a functional CCR5 and cannot be infected by CCR5 tropic viruses. In African populations (some in EA) we have delta24 CCR5 and the last time i did a flow cytometry experiment to assess expression it behaved the same way but this genotype but it is not well studied. There are also HLA variants that confer protection especially in discordant couples.
Good info BGL but boss,... come srow, come srow.... This is my question/scenerio (not their real names)Otieno hooks up with Nduku. Otieno suggests that they both go for a HIV tests. Nduku agrees, but has a hidden secret. She is positive but and has been on treatment for some time and viral load/count is undetectable. So she expects to show up as negative.... Even if they decided to go for repeat tests after six months, the results for Nduku will be the same as long as she remains on treatment. Is this a likely possibility? I think not. As long as the virus is there, even though the levels be low, the body will always mount an immune response to it i.e antibodies. And since the tests we routinely use are antibody-based, there you are. What say you @BGL? I agree with you @Rankaz Infact even if functional cure occurs [IF WE WILL ever ACHIEVE THAT] you still have remnants of memory B cells which you can detect by Elisa. Where did these docs go to? NYTimes Article wrote:He had Hodgkin’s lymphoma and received a bone-marrow transplant from a donor with the CCR5 mutation in May 2016. He, too, received immunosuppressive drugs, but the treatment was much less intense, in line with current standards for transplant patients.
He quit taking anti-H.I.V. drugs in September 2017, making him the first patient since Mr. Brown known to remain virus-free for more than a year after stopping.
Although the London patient was not as ill as Mr. Brown had been after the transplant, the procedure worked about as well: The transplant destroyed the cancer without harmful side effects. The transplanted immune cells, now resistant to H.I.V., seem to have fully replaced his vulnerable cells.
Most people with the H.I.V.-resistant mutation, called delta 32, are of Northern European descent. IciStem maintains a database of about 22,000 such donors.
So far, its scientists are tracking 38 H.I.V.-infected people who have received bone-marrow transplants, including six from donors without the mutation.
Even if a person harbors only a small number of X4 viruses, they may multiply in the absence of competition from their viral cousins. There is at least one reported case of an individual who got a transplant from a delta 32 donor but later rebounded with the X4 virus. (As a precaution against X4, Mr. Brown is taking a daily pill to prevent H.I.V. infection.)
Heck! @BGL are you Dr. Gupta? Of course i am not Gupta i remain BGL. I am still working on a functional cure for HIV. However i am worried by the reduced PEPFAR funding by the Trump administration. If Kenya Government does not fill up the gaps we will roll back all the gains made. Tuko pamoja Do you think this "supposed" cure can work for non european people? "There are only two emotions in the market, hope & fear. The problem is you hope when you should fear & fear when you should hope: - Jesse Livermore
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Rank: Veteran Joined: 10/11/2009 Posts: 1,223
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murchr wrote:BGL wrote:murchr wrote:BGL Posted : Friday, December 27, 2013 wrote:Rankaz13 wrote:JkMwatha wrote:BGL wrote:........
.....
Question 1 is well answered so i will not repeat and will go to question 2 thanks @Rankaz13
It is [NOT] true that a patient with undetectable viral load cannot transmit infection but [IT IS VERY RARE]. At this point let me say that most of the replication is occurring in the LYMPHOID tissues while we are only sampling the blood tissue. However, you all know it depends on the route of transmission.
There are also some people whom HIV infection with some viruses (CCR5 tropic) is impossible. For instance 1-2% of Caucasians with delta32 CCR5 do not express a functional CCR5 and cannot be infected by CCR5 tropic viruses. In African populations (some in EA) we have delta24 CCR5 and the last time i did a flow cytometry experiment to assess expression it behaved the same way but this genotype but it is not well studied. There are also HLA variants that confer protection especially in discordant couples.
Good info BGL but boss,... come srow, come srow.... This is my question/scenerio (not their real names)Otieno hooks up with Nduku. Otieno suggests that they both go for a HIV tests. Nduku agrees, but has a hidden secret. She is positive but and has been on treatment for some time and viral load/count is undetectable. So she expects to show up as negative.... Even if they decided to go for repeat tests after six months, the results for Nduku will be the same as long as she remains on treatment. Is this a likely possibility? I think not. As long as the virus is there, even though the levels be low, the body will always mount an immune response to it i.e antibodies. And since the tests we routinely use are antibody-based, there you are. What say you @BGL? I agree with you @Rankaz Infact even if functional cure occurs [IF WE WILL ever ACHIEVE THAT] you still have remnants of memory B cells which you can detect by Elisa. Where did these docs go to? NYTimes Article wrote:He had Hodgkin’s lymphoma and received a bone-marrow transplant from a donor with the CCR5 mutation in May 2016. He, too, received immunosuppressive drugs, but the treatment was much less intense, in line with current standards for transplant patients.
He quit taking anti-H.I.V. drugs in September 2017, making him the first patient since Mr. Brown known to remain virus-free for more than a year after stopping.
Although the London patient was not as ill as Mr. Brown had been after the transplant, the procedure worked about as well: The transplant destroyed the cancer without harmful side effects. The transplanted immune cells, now resistant to H.I.V., seem to have fully replaced his vulnerable cells.
Most people with the H.I.V.-resistant mutation, called delta 32, are of Northern European descent. IciStem maintains a database of about 22,000 such donors.
So far, its scientists are tracking 38 H.I.V.-infected people who have received bone-marrow transplants, including six from donors without the mutation.
Even if a person harbors only a small number of X4 viruses, they may multiply in the absence of competition from their viral cousins. There is at least one reported case of an individual who got a transplant from a delta 32 donor but later rebounded with the X4 virus. (As a precaution against X4, Mr. Brown is taking a daily pill to prevent H.I.V. infection.)
Heck! @BGL are you Dr. Gupta? Of course i am not Gupta i remain BGL. I am still working on a functional cure for HIV. However i am worried by the reduced PEPFAR funding by the Trump administration. If Kenya Government does not fill up the gaps we will roll back all the gains made. Tuko pamoja Do you think this "supposed" cure can work for non european people? This is not feasible outside of Research and Development. Firstly, it is a transplant! Therefore, there is a likelihood of rejection of the tissue if you are not immunosuppressive drugs which are 10 times more expensive than the current HIV drugs. History will not remember you for your IQ. It will remember you for what you did. “Genius is 1 percent inspiration, 99 percent perspiration.” Thomas Edison
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Rank: Elder Joined: 2/26/2012 Posts: 15,980
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BGL wrote:murchr wrote:BGL wrote:murchr wrote:BGL Posted : Friday, December 27, 2013 wrote:Rankaz13 wrote:JkMwatha wrote:BGL wrote:........
.....
Question 1 is well answered so i will not repeat and will go to question 2 thanks @Rankaz13
It is [NOT] true that a patient with undetectable viral load cannot transmit infection but [IT IS VERY RARE]. At this point let me say that most of the replication is occurring in the LYMPHOID tissues while we are only sampling the blood tissue. However, you all know it depends on the route of transmission.
There are also some people whom HIV infection with some viruses (CCR5 tropic) is impossible. For instance 1-2% of Caucasians with delta32 CCR5 do not express a functional CCR5 and cannot be infected by CCR5 tropic viruses. In African populations (some in EA) we have delta24 CCR5 and the last time i did a flow cytometry experiment to assess expression it behaved the same way but this genotype but it is not well studied. There are also HLA variants that confer protection especially in discordant couples.
Good info BGL but boss,... come srow, come srow.... This is my question/scenerio (not their real names)Otieno hooks up with Nduku. Otieno suggests that they both go for a HIV tests. Nduku agrees, but has a hidden secret. She is positive but and has been on treatment for some time and viral load/count is undetectable. So she expects to show up as negative.... Even if they decided to go for repeat tests after six months, the results for Nduku will be the same as long as she remains on treatment. Is this a likely possibility? I think not. As long as the virus is there, even though the levels be low, the body will always mount an immune response to it i.e antibodies. And since the tests we routinely use are antibody-based, there you are. What say you @BGL? I agree with you @Rankaz Infact even if functional cure occurs [IF WE WILL ever ACHIEVE THAT] you still have remnants of memory B cells which you can detect by Elisa. Where did these docs go to? NYTimes Article wrote:He had Hodgkin’s lymphoma and received a bone-marrow transplant from a donor with the CCR5 mutation in May 2016. He, too, received immunosuppressive drugs, but the treatment was much less intense, in line with current standards for transplant patients.
He quit taking anti-H.I.V. drugs in September 2017, making him the first patient since Mr. Brown known to remain virus-free for more than a year after stopping.
Although the London patient was not as ill as Mr. Brown had been after the transplant, the procedure worked about as well: The transplant destroyed the cancer without harmful side effects. The transplanted immune cells, now resistant to H.I.V., seem to have fully replaced his vulnerable cells.
Most people with the H.I.V.-resistant mutation, called delta 32, are of Northern European descent. IciStem maintains a database of about 22,000 such donors.
So far, its scientists are tracking 38 H.I.V.-infected people who have received bone-marrow transplants, including six from donors without the mutation.
Even if a person harbors only a small number of X4 viruses, they may multiply in the absence of competition from their viral cousins. There is at least one reported case of an individual who got a transplant from a delta 32 donor but later rebounded with the X4 virus. (As a precaution against X4, Mr. Brown is taking a daily pill to prevent H.I.V. infection.)
Heck! @BGL are you Dr. Gupta? Of course i am not Gupta i remain BGL. I am still working on a functional cure for HIV. However i am worried by the reduced PEPFAR funding by the Trump administration. If Kenya Government does not fill up the gaps we will roll back all the gains made. Tuko pamoja Do you think this "supposed" cure can work for non european people? This is not feasible outside of Research and Development. Firstly, it is a transplant! Therefore, there is a likelihood of rejection of the tissue if you are not immunosuppressive drugs which are 10 times more expensive than the current HIV drugs. Waa!! ok "There are only two emotions in the market, hope & fear. The problem is you hope when you should fear & fear when you should hope: - Jesse Livermore
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Rank: New-farer Joined: 12/28/2018 Posts: 70 Location: Helsingborg, Sweden
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I stil found this all unbelievable, even if someone invented somehow cure from aids it's just not possible to release as news cause major news outlets are controlled by private powerfull persons who will never push this agenda for small guy anyway and big one are not interested in making it;)
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Rank: Hello Joined: 7/19/2019 Posts: 3
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I'm not the doctor,but I think I can help you whith such question,because I was the viewer of such situation. My best friend is the HIV positive person,it's the long story of youth's stupidity. He is married one and his wife wanted children,but they were afraid. One good doctor helped them. After sex,wife went to HIV RNA test accuracy,that shown that all was OK. So,if you go to a good doctor,he will help you.Don't use drugs without doctor's permishion.
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Rank: New-farer Joined: 8/15/2019 Posts: 15
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BGL wrote:The problem is that we are fragmented and nobody knows what the other person is doing unless you meet at an international conference to present results. I & others are deeply involved trying to profile the prevalence of which coreceptor (R5 and X4) the viruses are using to enter the cell. Development of resistance against all the virus targets is very easy.... skip medication or the virus mutates under drug pressure BUT human gene will not be pressured by the virus to mutate. Remember in a patient, HIV is not clonal but exists as a quasi species. If only CCR5 exist then the patient can benefit but if CXCR4 then the patient is excluded. Also remember that all the other HIV therapies target the virus but this one targets the host (patient). Excellent idea guys. Thanks for sharing.
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Rank: Elder Joined: 2/26/2012 Posts: 15,980
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"There are only two emotions in the market, hope & fear. The problem is you hope when you should fear & fear when you should hope: - Jesse Livermore
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