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Kenyan discovers cure to Cervical Cancer!!
ecstacy
#1 Posted : Thursday, March 06, 2014 7:31:20 PM
Rank: Elder


Joined: 2/26/2008
Posts: 4,449
Hongera Dr Innocent Orora Maranga (KNH) & team!!

Away from the arts, this Kenyan has done well placing Kenya on the global supply side for solutions in science.

C & P
Researchers Dr Lynne and Dr Ian Hampson of Manchester University, UK and Dr Innocent Orora Maranga of KNH, put 40 cervical cancer patients on HIV drug lopinavir for two weeks.

When tested for cancer after three months, more than 90 per cent of the patients were found to be free of the disease.

“Out of 23 women initially diagnosed with high-grade disease, 19 returned to normal and two had low-grade disease. Furthermore, the 17 women initially diagnosed with borderline or low-grade disease also showed similar improvement,” said a statement from Manchester University.

The findings, if true, are nothing but a miracle in the treatment of cervical cancer especially in poor countries

Link - http://t.co/cnKMKTv5Fv #KOT
ecstacy
#2 Posted : Thursday, March 06, 2014 7:39:06 PM
Rank: Elder


Joined: 2/26/2008
Posts: 4,449
Cancer Research UK says it cannot comment on a trial that has not yet been peer-reviewed or published. “This is raising the hopes of patients,” warns a spokesman. “A peer review might find flaws in the trial. It may never get published.”

Even if further trials were successful, it could be years before this pessary becomes available. There is now talk of of a “window trial” – one in which lopinavir could be offered to women with high-grade disease while they are waiting for surgery. “The drug has been shown to be safe, and the women have nothing to lose and everything to gain. If it works they will not need an operation.

Meanwhile, the University of Manchester has filed a patent for treatment with lopinavir for HPV-related disease..
ecstacy
#3 Posted : Thursday, March 06, 2014 7:48:33 PM
Rank: Elder


Joined: 2/26/2008
Posts: 4,449
Their research work showed they needed a 10-fold higher concentration of the drug at the site of infection – the cervix – than you can get by taking the drug orally,” says Dr Hampson. “The obvious solution was to reformulate the drug, so it could be applied locally as a cream or pessary, and organise a clinical trial.”

But the cost of reformulating the drug meant there was little interest from drug companies, cancer charities or research agencies.

Then one of Dr Hampson’s PhD students, our own now (Dr) Innocent Orora Maranga, pointed out that one oral form of the drug available was a soft gelatin capsule, which might “melt very nicely” in the vagina, and could be trialled as a pessary. WINNER
ecstacy
#4 Posted : Thursday, March 06, 2014 7:52:56 PM
Rank: Elder


Joined: 2/26/2008
Posts: 4,449
There was another obstacle. In Europe the makers of the capsule had phased it out in favour of a hard tablet. A generic lopinavir capsule called Lopimune, made by an Indian company, was only licensed for Africa.

“I wanted to bring some Lopimune into the UK for a trial,” says Dr Hampson, “but it would have involved a lot of red tape – and would have cost a fortune. I felt as if I was banging my head against a brick wall.” Dr Hampson

The same PhD student, Dr Orora Maranga, pointed out how useful such a self-help treatment – if it worked – would be to women in Africa, where there are few screening programmes to pick up pre-cancerous conditions, or surgical facilities to treat them. WINNER

So it was that, near the end of 2011, they finally won approval from Kenyatta National Hospital in Nairobi (where Dr Maranga was then a senior registrar) for a preliminary trial of lopinavir in women with pre-cancerous cells in the cervix. In return they would set up a cervical-cancer screening programme – needed to identify women suitable for the trial – and facilities for surgery, if it was needed.
ecstacy
#5 Posted : Thursday, March 06, 2014 7:56:00 PM
Rank: Elder


Joined: 2/26/2008
Posts: 4,449
DONE. Pardon me for finding this more exciting than the Lupita Oscar winner excitements in Kenya! All in all though one will inspire dreams another will save lives. All WINNERS.
matata
#6 Posted : Thursday, March 06, 2014 8:22:55 PM
Rank: Member


Joined: 11/7/2011
Posts: 410
Goodnews! This will be a fortune for women globally! I hope it matures. And congratulations to our very able Pro Maranga.
Am worried with National schools scoring a mean grade of D, we may not have Professers 20 yrs from now.
Longe live Pro Maranga.
murchr
#7 Posted : Thursday, March 06, 2014 8:42:46 PM
Rank: Elder


Joined: 2/26/2012
Posts: 15,980
Was this part of his thesis? who is the maker of Lopinar/Lopimune? I know the pharmacetecal industry will try to fight this for business. This is awesome.
"There are only two emotions in the market, hope & fear. The problem is you hope when you should fear & fear when you should hope: - Jesse Livermore
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washiku
#8 Posted : Thursday, March 06, 2014 9:27:38 PM
Rank: Chief


Joined: 5/9/2007
Posts: 13,095
Applause Applause Applause Best news in a century. When I saw these news, we were in a group of 6 guys taking some tea. I was so excited that I started clapping. What was surprising me is that the people I was with, and even the other people in the restaurant were wondering what was so exciting. I just hope this initiative is supported. It could offer an entry to cure of all other type of cancers. This thing has really killed people.

This also goes to show how much more we could do if we invested much more in Research...unfortunately we need more money to pay salaries.Sad

But I know it may not be easy. There is no way nyeuthi will be allowed to come up with such a big thing.Sad
Buster
#9 Posted : Thursday, March 06, 2014 11:01:17 PM
Rank: Veteran


Joined: 5/17/2007
Posts: 1,345
This disease has taken a toll on my extended family. People have departed. Even now we have someone in hospital. I began texting everyone once I saw it on Telly. They say it only works if caught in its early stages. So my efforts to have all the females on that side get tested early has just got a boost.
Alba
#10 Posted : Thursday, March 06, 2014 11:32:09 PM
Rank: Elder


Joined: 12/27/2012
Posts: 2,256
Location: Bandalungwa
Si the Brits will get all the credit for this.
Rankaz13
#11 Posted : Friday, March 07, 2014 8:22:20 AM
Rank: Elder


Joined: 5/21/2013
Posts: 2,841
Location: Here
Buster wrote:
This disease has taken a toll on my extended family. People have departed. Even now we have someone in hospital. I began texting everyone once I saw it on Telly. They say it only works if caught in its early stages. So my efforts to have all the females on that side get tested early has just got a boost.


As you do so, remind them too of the HPV vaccine especially for the young pre-pubescent ones.
Life is like playing a violin solo in public and learning the instrument as one goes on.
murchr
#12 Posted : Wednesday, January 07, 2015 7:41:05 PM
Rank: Elder


Joined: 2/26/2012
Posts: 15,980
And then came this
NPR News wrote:
A drug that is used worldwide to treat malaria is now being tested as a treatment for cervical cancer. This surprising idea is the result of a new laboratory technique that could have far-reaching uses.

Our story starts with Dr. Richard Schlegel at Georgetown University Medical Center. He's best known for inventing the Gardasil vaccine to protect women from cervical cancer.

Schlegel wished he could take cancer cells from women who came to the hospital for treatment and grow them in the lab to learn more about this disease.
"People have tried growing cells in culture before, but they've been very crude experiments, essentially," he says. Most of these freshly collected cells die off quickly in the lab.

But Schlegel had an idea for a radically new method to grow all sorts of human cells. The secret to keeping them alive indefinitely is to grow them on a bed of cells that come from mice. These mouse cells have been blasted with radiation to prevent them from multiplying, and the culture is then treated with a compound (called a ROCK inhibitor) that regulates cell growth.


Source: http://www.npr.org/blogs...-cells-thrive-in-the-lab
"There are only two emotions in the market, hope & fear. The problem is you hope when you should fear & fear when you should hope: - Jesse Livermore
.
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